The results of Figure 1 in the primary article demonstrate that chemokines, combined with DNA, can form nanoparticles

The results of Figure 1 in the primary article demonstrate that chemokines, combined with DNA, can form nanoparticles

Pre-Project Assignment

Outline

Provide an outline. This is NOT a script, but a plan for the BIG ideas you want to share.

***An example of how the outline should look like is attached and mentioned on the last page. Please refer***

Below are the links to your topic and the articles that you’ll be using to complete the outline.

  1. Links:

Popular article:

https://www.sciencedaily.com/releases/2022/07/220715142138.htm

Peer-reviewed primary article cited by the popular article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161158/

Peer-reviewed review:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400988/

  • The figure I will be explaining.

In this situation, I will explain figure 1 from the peer-reviewed primary article, representing the kinetic parameters of the Toll-like receptor 4 (TLR4) signaling cascade. This figure illustrates how Chemokines can combine with DNA to form nanoparticles, which can significantly increase the immune system’s inflammatory response triggered by TLR. In this figure, the blue circles are used to represent DNA, while the green circles are used to represent chemokines. The red arrows represent TLR-driven immune inflammation. This figure shows that nanoparticles are formed when chemokines and DNA interact (Du, 2022). These nanoparticles are thus positioned to activate the TLR-driven immune inflammation, which is the crucial component of the immune response.

3. The main finding from the figure.

The results of Figure 1 in the primary article demonstrate that chemokines, combined with DNA, can form nanoparticles with the capacity to superinduce TLR-driven immune inflammation. This activation of the TLR-driven inflammatory response is an essential immune response component. This suggests that chemokines are important in regulating the immune response (Du, 2022).

  • Is this finding the main finding that was discussed in the popular article?

             The findings from figure 1 of the peer-reviewed primary article were discussed in the popular article. The data presented in this article suggests that chemokines are essential for managing the immune system’s response. This notion is the article’s primary focus and goes beyond the scope of the figure. The popular article discussed how the immune system could be modulated by chemokines and by recruitment and inflammation of immune cell mediation (Du, 2022). The popular article also discusses how chemokines can target particular immune cells useful in treating various diseases.

References

Du, Y., Ah Kioon, M. D., Laurent, P., Chaudhary, V., Pierides, M., Yang, C., … & Barrat, F. J. (2022). Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Journal of Experimental Medicine, 219(7), e20212142.

Vilgelm, Anna E, and Ann Richmond. “Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy.” Frontiers in Immunology, U.S. National Library of Medicine, 27 Feb 2019

Example of the outline

This is not meant to be a specific template, but to give you a sense of the things I am looking for in how you will lay out your video.  Please adjust this to fit your own style and change the order, but this would be an example of how you could lay it out.  Again, you need to be specific.  For example, you can’t just say “prevalence.”  You would have to say “1 in 100,000 children in the US” for your outline

  1. Summary of popular news article
    1. SARS-Cov2 immune overview
      1. Virus, inside our cells
      1. We have to kill our cells to kill the virus
    1. Complement – Proteins that specifically bind to pathogens that are a problem and poke holes in it
    1. Overactivation of complement was seen in severe COVID-19
    1. Is this surprising?  Kind of?  It might mean that complement might actually be causing problems… possibly even hurting our own cells?
  2. Figure
    1. Explain flow of study with comparison with flu and COVID patients
      1. Explain similarities and differences between flu and COVID – both respiratory viruses, slightly different immune responses triggered, flu more sensitive to fever, etc
    1. Walk through the figure
      1. Each dot is a person
      1. Higher up, the more complement
      1. Can see the averages and see more complement in COVID
  3. So what?
    1. We often cause some of our own problems during an infection
    1. Maybe treatments to reduce complement levels may help prevent severe COVID

Answer preview for the paper on ‘The results of Figure 1 in the primary article demonstrate that chemokines, combined with DNA, can form nanoparticles’

primary article demonstrate that chemokines

APA 407 words

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